Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

ABSTRACT:

Objective

Multiple sclerosis (MS) is a disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Based on infiltrating immune cells, deposition of humoral factors and loss of oligodendrocytes and/or myelin proteins, four lesion patterns have been described. Pattern II is characterized by antibody and complement deposition in addition to T-cell infiltration. MS is considered a T-cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Our objective was to identify, isolate, and characterize brain-infiltrating clonally expanded T cells in pattern II MS lesions.

Methods

We used next-generation sequencing to i

SUBMITTER: Planas R 

PROVIDER: S-EPMC4574806 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature