Small bowel resection induces long-term changes in the enteric microbiota of mice.

ABSTRACT:

Purpose

The enteric microbiome is known to play a major role in healthy gut homeostasis and several disease states. It may also contribute to both the intestinal recovery and complications that occur in patients with short bowel syndrome. The extent and nature of alterations to the gut microbiota following intestinal resection, however, are not well studied in a controlled setting. The purpose of this investigation is to characterize the effects of massive small bowel resection on the murine enteric microflora.

Methods

Wild-type C57BL6 mice, following a week of acclamation to a liquid rodent diet, underwent either 50% proximal small bowel resection (SBR) or a sham operation. Mice were sacrificed, and enteric contents from the small bowel, cecum, and stool were harvested at 7

SUBMITTER: Sommovilla J 

PROVIDER: S-EPMC4576885 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature