Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.

ABSTRACT:

Background

Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.

Methods

Seventy-eight cases were subjected to whole-exome (n = 18) and targeted deep sequencing (n = 60).

Results

While the most common mutation was in TP53, the OTSCC genetic landscape differed from previously described cohorts of patients with head and neck

SUBMITTER: Vettore AL 

PROVIDER: S-EPMC4580363 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature