Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.

ABSTRACT:

Background

Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.

Methods

In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We comple

SUBMITTER: Vimaleswaran KS 

PROVIDER: S-EPMC4582411 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature