Bone strain magnitude is correlated with bone strain rate in tetrapods: implications for models of mechanotransduction.

ABSTRACT: Hypotheses suggest that structural integrity of vertebrate bones is maintained by controlling bone strain magnitude via adaptive modelling in response to mechanical stimuli. Increased tissue-level strain magnitude and rate have both been identified as potent stimuli leading to increased bone formation. Mechanotransduction models hypothesize that osteocytes sense bone deformation by detecting fluid flow-induced drag in the bone's lacunar-canalicular porosity. This model suggests that the osteocyte's intracellular response depends on fluid-flow rate, a product of bone strain rate and gradient, but does not provide a mechanism for detection of strain magnitude. Such a mechanism is necessary for bone modelling to adapt to loads, because strain magnitude is an important determinant of skeletal

SUBMITTER: Aiello BR 

PROVIDER: S-EPMC4590470 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature