A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4⁺ T cell receptor repertoire clonality.

ABSTRACT: T and B cell receptor (TCR and BCR, respectively) Vβ or immunoglobulin heavy chain complementarity-determining region 3 sequencing allows monitoring of repertoire changes through recognition, clonal expansion, affinity maturation, and T or B cell activation in response to antigen. TCR and BCR repertoire analysis can advance understanding of antitumor immune responses in the tumor microenvironment. TCR and BCR repertoires of sorted CD4⁺, CD8⁺ or CD19⁺ cells in tumor, non-tumoral distant tissue (NT), and peripheral compartments (blood/draining lymph node [P]) from 47 non-small cell lung cancer (NSCLC) patients (age_median = 68 y) were sequenced. The clonotype spectra were assessed among different tissues and correlated with clinical and immunologica

SUBMITTER: Zhu W 

PROVIDER: S-EPMC4635865 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature