Association between ErbB3 genetic polymorphisms and coronary artery disease in the Han and Uyghur populations of China.

ABSTRACT:

Background

ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. Recent research has shown that amplification of this gene is related to prostate, bladder and breast cancers, as well as low-density lipoprotein cholesterol (LDL-C) metabolism. LDL-C plays a considerable role in the development of cardiovascular disease. Thus, the present study assessed the association between human ErbB3 gene polymorphisms and coronary artery disease (CAD) in Han and Uygur populationsin China.

Methods

We performed two independent case-control studies with a Han population (339 CAD patients and 395 control subjects) and a Uygur population (306 CAD patients and 325 control subjects). All of the CAD patients and controls were genotyped for the

SUBMITTER: Maitusong B 

PROVIDER: S-EPMC4659067 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature