Ontology highlight
ABSTRACT:
SUBMITTER: Sperber H
PROVIDER: S-EPMC4662931 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Nature cell biology 20151116 12
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types. Recently, it has been recognized that embryonic stem cells derived from both mice and humans exhibit two stable yet epigenetically distinct states of pluripotency: naive and primed. We now show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs). Specifically, in ...[more]