Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.

ABSTRACT: Influenza virus (IFV) infection is a common cause of severe viral pneumonia associated with acute respiratory distress syndrome (ARDS), which is difficult to control with general immunosuppressive therapy including corticosteroids due to the unfavorable effect on viral replication. Studies have suggested that the excessive activation of the innate immunity by IFV is responsible for severe pathologies. In this study, we focused on CARD9, a signaling adaptor known to regulate innate immune activation through multiple innate sensor proteins, and investigated its role in anti-IFV defense and lung pathogenesis in a mouse model recapitulating severe influenza pneumonia with ARDS. We found that influenza pneumonia was dramatically attenuated in Card9-deficient mice, which showed improved mortalit

SUBMITTER: Uematsu T 

PROVIDER: S-EPMC4667252 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature