A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection.
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ABSTRACT:
SUBMITTER: Bauer M
PROVIDER: S-EPMC8682987 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection.
Bauer Michael M Gomez-Gonzalez Alfonso A Suomalainen Maarit M Schilling Nicolas N Hemmi Silvio S Greber Urs F UF
Science advances 20211217 51
Antiviral defense and virus exclusion from the cell nucleus restrict foreign nucleic acid influx and infection. How the genomes of DNA viruses evade cytosolic pattern recognition and cross the nuclear envelope is incompletely understood. Here, we show that the virion protein V of adenovirus functions as a linchpin between the genome and the capsid, thereby securing particle integrity. Absence of protein V destabilizes cytoplasmic particles and promotes premature genome release, raising cytokine ...[more]
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