Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.

ABSTRACT: A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configura

SUBMITTER: Pezzulo G 

PROVIDER: S-EPMC4667987 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature