Center-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation.

ABSTRACT:

Background

Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood.

Objectives

We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period.

Patients/methods

Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression m

SUBMITTER: Tosetto A 

PROVIDER: S-EPMC4670074 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature