Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis.

ABSTRACT:

Purpose

Previous studies have reported the association of an insertion/deletion (Ins/Del) polymorphism (rs3783553) in the 3' untranslated region of interleukin-1A (IL-1A) with the risk of cancer, such as oral squamous cell carcinoma, nasopharyngeal carcinoma, and cervical carcinoma. However, the results are still inconsistent. The present meta-analysis aimed to clarify the association of IL-1A rs3783553 polymorphism with cancer risk.

Methods

All eligible studies were selected from PubMed, Web of Science, and Chinese National Knowledge Infrastructure up to September 2, 2015. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate cancer risk.

Results

A total of ten case-control studies with 4,514 cases and 6,689 controls were included this me

SUBMITTER: Ma L 

PROVIDER: S-EPMC4690651 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature