Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort.

ABSTRACT:

Background

There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.

Methods

This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression.

Results

We ide

SUBMITTER: Bogdanova TI 

PROVIDER: S-EPMC4705885 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature