Ontology highlight
ABSTRACT:
SUBMITTER: Camps J
PROVIDER: S-EPMC4721599 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Camps Jordi J Nguyen Quang Tri QT Padilla-Nash Hesed M HM Knutsen Turid T McNeil Nicole E NE Wangsa Danny D Hummon Amanda B AB Grade Marian M Ried Thomas T Difilippantonio Michael J MJ
Genes, chromosomes & cancer 20091101 11
To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic hybridization (aCGH), and array-based global gene expression profiling on 31 primary carcinomas and 15 established cell lines. Importantly, aCGH showed that the genomic profiles of primary tumors are recapitulated in the cell lines. We revealed a preponderance of chromosome breakpoints at sites of copy number variants (CNVs) i ...[more]