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Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis.

ABSTRACT: Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.

SUBMITTER: Chen J

PROVIDER: S-EPMC4751885 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis.

Chen Jie J Koswatta Panduka P DeBergh J Robb JR Fu Peng P Pan Ende E MacMillan John B JB Ready Joseph M JM

Chemical science 20150312 5

Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity. ...[more]

PMID: 26877863

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