Genetic basis of TNF-α antagonist associated psoriasis in inflammatory bowel diseases: a genotype-phenotype analysis.

ABSTRACT:

Background

Anti-tumour necrosis factor (anti-TNF) biologic associated psoriasis has been reported in inflammatory bowel disease (IBD) patients. However, little is known regarding its pathogenesis.

Aim

To identify potential genetic predispositions to anti-TNF associated psoriasis in IBD patients.

Methods

This retrospective chart review included IBD patients enrolled in a prospective registry. Cases of anti-TNF associated psoriasis and idiopathic psoriasis unrelated to anti-TNF exposure were confirmed by an expert dermatologist. All patients were genotyped on the Illumina Immunochip. A weighted genetic risk score ascertaining genetic pre-disposition towards psoriasis was calculated and overall genetic pre-disposition as well as differential distribution of individual po

SUBMITTER: Vedak P 

PROVIDER: S-EPMC4755796 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature