Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice.

ABSTRACT:

Background

Transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a Ca(2+)-binding protein that regulates Ca(2+) homeostasis through gene regulation and protein-protein interactions. It has been shown that a dominant active form (daDREAM) is implicated in learning-related synaptic plasticity such as LTP and LTD in the hippocampus. Neuronal spines are reported to play important roles in plasticity and memory. However, the possible role of DREAM in spine plasticity has not been reported.

Results

Here we show that potentiating DREAM activity, by overexpressing daDREAM, reduced dendritic basal arborization and spine density in CA1 pyramidal neurons and increased spine density in dendrites in dentate gyrus granule cells. These microanatomical chan

SUBMITTER: Mellstrom B 

PROVIDER: S-EPMC4772309 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature