Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice.
Ontology highlight
ABSTRACT: Background
Transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a Ca(2+)-binding protein that regulates Ca(2+) homeostasis through gene regulation and protein-protein interactions. It has been shown that a dominant active form (daDREAM) is implicated in learning-related synaptic plasticity such as LTP and LTD in the hippocampus. Neuronal spines are reported to play important roles in plasticity and memory. However, the possible role of DREAM in spine plasticity has not been reported.Results
Here we show that potentiating DREAM activity, by overexpressing daDREAM, reduced dendritic basal arborization and spine density in CA1 pyramidal neurons and increased spine density in dendrites in dentate gyrus granule cells. These microanatomical changes are accompanied by significant modifications in the expression of specific genes encoding the cytoskeletal proteins Arc, Formin 1 and Gelsolin in daDREAM hippocampus.Conclusions
Our results strongly suggest that DREAM plays an important role in structural plasticity in the hippocampus.
SUBMITTER: Mellstrom B
PROVIDER: S-EPMC4772309 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice.
Mellström Britt B Kastanauskaite Asta A Knafo Shira S Gonzalez Paz P Dopazo Xose M XM Ruiz-Nuño Ana A Jefferys John G R JG Zhuo Min M Bliss Tim V P TV Naranjo Jose R JR DeFelipe Javier J
Molecular brain 20160229
<h4>Background</h4>Transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a Ca(2+)-binding protein that regulates Ca(2+) homeostasis through gene regulation and protein-protein interactions. It has been shown that a dominant active form (daDREAM) is implicated in learning-related synaptic plasticity such as LTP and LTD in the hippocampus. Neuronal spines are reported to play important roles in plasticity and memory. However, the possible role of DREAM in spine pl ...[more]
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