Dataset Information
No Promoter Left Behind (NPLB): learn de novo promoter architectures from genome-wide transcription start sites.
Ontology highlight
ABSTRACT: Unlabelled
Promoters have diverse regulatory architectures and thus activate genes differently. For example, some have a TATA-box, many others do not. Even the ones with it can differ in its position relative to the transcription start site (TSS). No Promoter Left Behind (NPLB) is an efficient, organism-independent method for characterizing such diverse architectures directly from experimentally identified genome-wide TSSs, without relying on known promoter elements. As a test case, we show its application in identifying novel architectures in the fly genome.Availability and implementation
Web-server at http://nplb.ncl.res.in Standalone also at https://github.com/computationalBiology/NPLB/ (Mac OSX/Linux).Contact
l.narlikar@ncl.res.inSupplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Mitra S
PROVIDER: S-EPMC4795619 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
No Promoter Left Behind (NPLB): learn de novo promoter architectures from genome-wide transcription start sites.
Bioinformatics (Oxford, England) 20151102 5
<h4>Unlabelled</h4>Promoters have diverse regulatory architectures and thus activate genes differently. For example, some have a TATA-box, many others do not. Even the ones with it can differ in its position relative to the transcription start site (TSS). No Promoter Left Behind (NPLB) is an efficient, organism-independent method for characterizing such diverse architectures directly from experimentally identified genome-wide TSSs, without relying on known promoter elements. As a test case, we s ...[more]