A model to predict survival following pancreaticoduodenectomy for malignancy based on tumour site, stage and lymph node ratio.

ABSTRACT:

Background

Site of tumour origin, lymph node metastases and lymph node ratio (LNR) are identified as important factors determining prognosis in patients undergoing pancreaticoduodenectomy (PD). This study hypothesised that a prognostic index to predict survival could be developed through statistical modelling based on these pathological variables.

Methods

Patients who underwent PD between 2004 and 2013 were included. Univariable and multivariable (Cox regression) analyses were performed to identify predictors of survival, and a prognostic index was derived. The prognostic index was then validated using an external patient cohort.

Results

A total of 567 patients who underwent PD were used as a derivation cohort. Tumour site (p < 0.001), tumour size (p = 0.002), T-stage

SUBMITTER: Dasari BV 

PROVIDER: S-EPMC4814610 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature