MRI surrogates for molecular subgroups of medulloblastoma.

ABSTRACT:

Background and purpose

Recently identified molecular subgroups of medulloblastoma have shown potential for improved risk stratification. We hypothesized that distinct MR imaging features can predict these subgroups.

Materials and methods

All patients with a diagnosis of medulloblastoma at one institution, with both pretherapy MR imaging and surgical tissue, served as the discovery cohort (n = 47). MR imaging features were assessed by 3 blinded neuroradiologists. NanoString-based assay of tumor tissues was conducted to classify the tumors into the 4 established molecular subgroups (wingless, sonic hedgehog, group 3, and group 4). A second pediatric medulloblastoma cohort (n = 52) from an independent institution was used for validation of the MR imaging features predictive of

SUBMITTER: Perreault S 

PROVIDER: S-EPMC4819007 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature