Umbilical cord gene expression reveals the molecular architecture of the fetal inflammatory response in extremely preterm newborns.

ABSTRACT:

Background

The fetal inflammatory response (FIR) in placental membranes to an intrauterine infection often precedes premature birth raising neonatal mortality and morbidity. However, the precise molecular events behind FIR still remain largely unknown, and little has been investigated at gene expression level.

Methods

We collected publicly available microarray expression data profiling umbilical cord (UC) tissue derived from the cohort of extremely low gestational age newborns (ELGANs) and interrogate them for differentially expressed (DE) genes between FIR and non-FIR-affected ELGANs.

Results

We found a broad and complex FIR UC gene expression signature, changing up to 19% (3,896/20,155) of all human genes at 1% false discovery rate. Significant changes of a minimum

SUBMITTER: Costa D 

PROVIDER: S-EPMC4823644 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature