Dataset Information

Cerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson's Disease.

ABSTRACT:

Purpose

To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET).

Methods

Three groups of patients were recruited in this study including PD patients with dementia (PDD; n = 10), with mild cognitive impairment (PD-MCI; n = 20), and with no cognitive impairment (PD-NC; n = 30). The groups were matched for age, sex, education, disease duration, motor disability, levodopa equivalent dose and Geriatric Depression Rating Scale (GDS) score. All subjects underwent a FDG-PET study. Maps of regional metabolism in the three groups were compared using statistical parametric mapping (SPM5).

Results

PD-MCI patients exhibited limited areas of hypometabolism in the frontal, temporal and parahippocampal gyrus compared with the PD-NC patients (p < 0.01). PDD patients had bilateral areas of hypometabolism in the frontal and posterior parietal-occipital lobes compared with PD-MCI patients (p < 0.01), and exhibited greater metabolic reductions in comparison with PD-NC patients (p < 0.01).

Conclusions

Compared with PD-NC patients, hypometabolism was much higher in the PDD patients than in PD-MCI patients, mainly in the posterior cortical areas. The result might suggest an association between posterior cortical hypometabolism and more severe cognitive impairment. PD-MCI might be important for early targeted therapeutic intervention and disease modification.

SUBMITTER: Tang Y

PROVIDER: S-EPMC4827825 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Cerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson's Disease.

Tang Yilin Y Ge Jingjie J Liu Fengtao F Wu Ping P Guo Sisi S Liu Zhenyang Z Wang Yixuan Y Wang Ying Y Ding Zhengtong Z Wu Jianjun J Zuo Chuantao C Wang Jian J

PloS one 20160411 4

<h4>Purpose</h4>To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET).<h4>Methods</h4>Three groups of patients were recruited in this study including PD patients with dementia (PDD; n = 10), with mild cognitive impairment (PD-MCI; n = 20), and with no cognitive impairment (PD-NC; n = 30). The groups were matched for age, sex, education, disease duration, motor di ...[more]

PMID: 27064684

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Dataset Information

Cerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson's Disease.

Purpose

Methods

Results

Conclusions

Publications

Cerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson's Disease.

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