Ontology highlight
ABSTRACT:
SUBMITTER: Ancelin K
PROVIDER: S-EPMC4829419 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
eLife 20160202
Upon fertilization, the highly specialised sperm and oocyte genomes are remodelled to confer totipotency. The mechanisms of the dramatic reprogramming events that occur have remained unknown, and presumed roles of histone modifying enzymes are just starting to be elucidated. Here, we explore the function of the oocyte-inherited pool of a histone H3K4 and K9 demethylase, LSD1/KDM1A during early mouse development. KDM1A deficiency results in developmental arrest by the two-cell stage, accompanied ...[more]