Dataset Information
Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Feng Z
PROVIDER: S-EPMC4855835 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.
Chemical communications (Cambridge, England) 20160418 37
Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 μM) towards an osteosarcoma cell line. ...[more]