Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.

ABSTRACT: Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 μM) towards an osteosarcoma cell line.

SUBMITTER: Feng Z 

PROVIDER: S-EPMC4855835 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature