The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample.
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ABSTRACT:
SUBMITTER: Oedegaard KJ
PROVIDER: S-EPMC4857276 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample.
Oedegaard Ketil J KJ Alda Martin M Anand Anit A Andreassen Ole A OA Balaraman Yokesh Y Berrettini Wade H WH Bhattacharjee Abesh A Brennand Kristen J KJ Burdick Katherine E KE Calabrese Joseph R JR Calkin Cynthia V CV Claasen Ana A Coryell William H WH Craig David D DeModena Anna A Frye Mark M Gage Fred H FH Gao Keming K Garnham Julie J Gershon Elliot E Jakobsen Petter P Leckband Susan G SG McCarthy Michael J MJ McInnis Melvin G MG Maihofer Adam X AX Mertens Jerome J Morken Gunnar G Nievergelt Caroline M CM Nurnberger John J Pham Son S Schoeyen Helle H Shekhtman Tatyana T Shilling Paul D PD Szelinger Szabolcs S Tarwater Bruce B Yao Jun J Zandi Peter P PP Kelsoe John R JR
BMC psychiatry 20160505
<h4>Background</h4>Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization and prophylaxis using mood-stabilizing medications to reduce both manic and depressive symptoms. Lithium remains the gold standard of treatment with the strongest data for both efficacy and suicide prevention. However, many patients do not respond to this medication, and c ...[more]
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