Human newborn bacille Calmette-Guerin vaccination and risk of tuberculosis disease: a case-control study.

ABSTRACT:

Background

An incomplete understanding of the immunological mechanisms underlying protection against tuberculosis (TB) hampers the development of new vaccines against TB. We aimed to define host correlates of prospective risk of TB disease following bacille Calmette-Guérin (BCG) vaccination.

Methods

In this study, 5,726 infants vaccinated with BCG at birth were enrolled. Host responses in blood collected at 10 weeks of age were compared between infants who developed pulmonary TB disease during 2 years of follow-up (cases) and those who remained healthy (controls).

Results

Comprehensive gene expression and cellular and soluble marker analysis failed to identify a correlate of risk. We showed that distinct host responses after BCG vaccination may be the reason: two majo

SUBMITTER: Fletcher HA 

PROVIDER: S-EPMC4869393 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature