A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells.

ABSTRACT: Despite the increasing importance of long noncoding RNA in physiology and disease, their role in endothelial biology remains poorly understood. Growing evidence has highlighted them to be essential regulators of human embryonic stem cell differentiation. SENCR, a vascular-enriched long noncoding RNA, overlaps the Friend Leukemia Integration virus 1 (FLI1) gene, a regulator of endothelial development. Therefore, we wanted to test the hypothesis that SENCR may contribute to mesodermal and endothelial commitment as well as in endothelial function. We thus developed new differentiation protocols allowing generation of endothelial cells from human embryonic stem cells using both directed and hemogenic routes. The expression of SENCR was markedly regulated during endothelial commitment using bot

SUBMITTER: Boulberdaa M 

PROVIDER: S-EPMC4876031 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature