Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis.

ABSTRACT:

Background and aims

Ulcerative colitis (UC) is associated with increased dietary intake of fat and n-6 polyunsaturated fatty acids (PUFA). Modification of fat metabolism may alter inflammation and disease severity. Our aim was to assess differences in dietary and serum fatty acid levels between control and UC subjects and associations with disease activity and inflammatory cytokines.

Methods

Dietary histories, serum, and colonic tissue samples were prospectively collected from 137 UC subjects and 38 controls. Both histologic injury and the Mayo Disease Activity Index were assessed. Serum and tissue cytokines were measured by Luminex assay. Serum fatty acids were obtained by gas chromatography.

Results

UC subjects had increased total fat and oleic acid (OA) intake, but

SUBMITTER: Wiese DM 

PROVIDER: S-EPMC4882051 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature