Genome-wide identification and analysis of miRNA-related single nucleotide polymorphisms (SNPs) in rice.

ABSTRACT:

Background

MiRNAs are key regulators in the miRNA-mediated regulatory networks. Single nucleotide polymorphisms (SNPs) that occur at miRNA-related regions may cause serious phenotype changes. To gain new insights into the evolution of miRNAs after SNP variation, we performed a genome-wide scan of miRNA-related SNPs, and analyzed their effects on the stability of miRNAs structure and the alteration of target spectrum in rice.

Results

We find that the SNP density in pre-miRNAs is significantly higher than that in the flanking regions, owing to the rapid evolution of a large number of species-specific miRNAs in rice. In contrast, it is obvious that deeply conserved miRNAs are under strong purifying selection during evolution. In most cases, the SNPs in stem regions may result i

SUBMITTER: Liu Q 

PROVIDER: S-EPMC4883715 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature