Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4907130 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wang Xiaowei X Shaw Dana K DK Sakhon Olivia S OS Snyder Greg A GA Sundberg Eric J EJ Santambrogio Laura L Sutterwala Fayyaz S FS Dumler J Stephen JS Shirey Kari Ann KA Perkins Darren J DJ Richard Katharina K Chagas Andrezza C AC Calvo Eric E Kopecký Jan J Kotsyfakis Michail M Pedra Joao H F JHF
Infection and immunity 20160524 6
Tick saliva contains a number of effector molecules that inhibit host immunity and facilitate pathogen transmission. How tick proteins regulate immune signaling, however, is incompletely understood. Here, we describe that loop 2 of sialostatin L2, an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflammasome during infection with the rickettsial agent Anaplasma phagocytophilum Macrophages deficient in annexin A2 secreted significantly smaller amounts ...[more]