Ontology highlight
ABSTRACT:
SUBMITTER: Kim do Y
PROVIDER: S-EPMC4924752 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Kim Do Yeon do Y Park Eun Young EY Chang EunSun E Kang Hyeok-Gu HG Koo Yoonjin Y Lee Eun Ji EJ Ko Je Yeong JY Kong Hyun Kyung HK Chun Kyung-Hee KH Park Jong Hoon JH
Oncotarget 20160301 12
One of the properties of human breast cancer cells is cancer stemness, which is characterized by self-renewal capability and drug resistance. Protein kinase D1 (PRKD1) functions as a key regulator of many cellular processes and is downregulated in invasive breast cancer cells. In this study, we found that PRKD1 was upregulated in MCF-7-ADR human breast cancer cells characterized by drug resistance. Additionally, we discovered that PRKD1 expression was negatively regulated by miR-34a binding to t ...[more]