Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation.
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ABSTRACT:
SUBMITTER: Yoo MH
PROVIDER: S-EPMC4926223 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation.
Yoo Min Heui MH Kim Tae-Youn TY Yoon Young Hee YH Koh Jae-Young JY
Scientific reports 20160629
To investigate the role of synaptic zinc in the ASD pathogenesis, we examined zinc transporter 3 (ZnT3) null mice. At 4-5 weeks of age, male but not female ZnT3 null mice exhibited autistic-like behaviors. Cortical volume and neurite density were significantly greater in male ZnT3 null mice than in WT mice. In male ZnT3 null mice, consistent with enhanced neurotrophic stimuli, the level of BDNF as well as activity of MMP-9 was increased. Consistent with known roles for MMPs in BDNF upregulation, ...[more]
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