Understanding NIH clinical case definitions for pediatric intrathoracic TB by applying them to a clinical trial.

ABSTRACT:

Setting

Standardized clinical case definitions represent the best option for pediatric tuberculosis (TB) disease diagnosis and classification.

Objective

To apply published guidelines for intrathoracic TB classification for use in reporting diagnostic studies with passive case finding to presumed TB patients from International Maternal Pediatric Adolescent AIDS Clinical Trials P1041, a trial of isoniazid prophylaxis in healthy human immunodeficiency virus exposed, bacille Calmette-Guérin vaccinated infants which employed active surveillance to assess a novel application of these guidelines in this setting.

Methods

P1041 presumed TB patients were retrospectively cross-classified by protocol-defined and National Institutes of Health (NIH) classifications, and agreement w

SUBMITTER: Beneri CA 

PROVIDER: S-EPMC4928853 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature