Prognostic significance of circulating laminin gamma2 for early-stage non-small-cell lung cancer.

ABSTRACT:

Background

Laminin gamma2 (Ln-γ2) chain, a distinctive subunit of heterotrimeric laminin-332, is frequently upregulated in carcinomas and is of great importance in cell migration and invasion. Despite this, the status of circulating Ln-γ2 in lung cancer patients is still uncertain.

Patients and methods

In this retrospective study, serum samples from 538 all-stage (stages I-IV) patients with non-small-cell lung cancer (NSCLC) and 94 age-matched healthy volunteers were investigated by enzyme-linked immunosorbent assay. Data were statistically analyzed in combination with clinicopathological information.

Results

Circulating Ln-γ2 was markedly increased in NSCLC, even in stage I cases (P<0.01), reflecting the progression of lung cancer. Survival analysis on 370 eligible p

SUBMITTER: Teng Y 

PROVIDER: S-EPMC4939988 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature