Investigation of 2 models to set and evaluate quality targets for hb a1c: biological variation and sigma-metrics.

ABSTRACT:

Background

A major objective of the IFCC Task Force on Implementation of HbA1c Standardization is to develop a model to define quality targets for glycated hemoglobin (Hb A1c).

Methods

Two generic models, biological variation and sigma-metrics, are investigated. We selected variables in the models for Hb A1c and used data of external quality assurance/proficiency testing programs to evaluate the suitability of the models to set and evaluate quality targets within and between laboratories.

Results

In the biological variation model, 48% of individual laboratories and none of the 26 instrument groups met the minimum performance criterion. In the sigma-metrics model, with a total allowable error (TAE) set at 5 mmol/mol (0.46% NGSP), 77% of the individual laboratories and

SUBMITTER: Weykamp C 

PROVIDER: S-EPMC4946649 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature