Investigation of Underlying Biological Association and Targets between Rejection of Renal Transplant and Renal Cancer.

ABSTRACT:

Background

Post-renal transplant patients have a high likelihood of developing renal cancer. However, the underlying biological mechanisms behind the development of renal cancer in post-kidney transplant patients remain to be elucidated. Therefore, this study aimed to investigate the underlying biological mechanism behind the development of renal cell carcinoma in post-renal transplant patients.

Methods

Next-generation sequencing data and corresponding clinical information of patients with clear cell renal cell carcinoma (ccRCC) were obtained from The Cancer Genome Atlas Program (TCGA) database. The microarray data of kidney transplant patients with or without rejection response was obtained from the Gene Expression Omnibus (GEO) database. In addition, statistical analysis w

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10229252 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature