Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.

ABSTRACT: Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G×E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. In a first demonstration of this approach in a G×E predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes HTR1A, HTR2A, HTR2C, and 2 in TPH2). Analyses focused on 2 forms of interpersonal stress as environmental risk factors. Using 5 years of longitudinal diagnostic and life stress interviews from 387 emerging young adults in the Youth Emotion Project, survival analyses show

SUBMITTER: Vrshek-Schallhorn S 

PROVIDER: S-EPMC4948188 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature