Optimally controlling the human connectome: the role of network topology.

ABSTRACT: To meet ongoing cognitive demands, the human brain must seamlessly transition from one brain state to another, in the process drawing on different cognitive systems. How does the brain's network of anatomical connections help facilitate such transitions? Which features of this network contribute to making one transition easy and another transition difficult? Here, we address these questions using network control theory. We calculate the optimal input signals to drive the brain to and from states dominated by different cognitive systems. The input signals allow us to assess the contributions made by different brain regions. We show that such contributions, which we measure as energy, are correlated with regions' weighted degrees. We also show that the network communicability, a measure of d

SUBMITTER: Betzel RF 

PROVIDER: S-EPMC4965758 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature