Body fat distribution, menopausal hormone therapy and incident type 2 diabetes in postmenopausal women of the MESA study.

ABSTRACT:

Objectives

We investigated the association between menopausal hormone therapy (MHT) and incident type 2 diabetes in postmenopausal women, and explored the potential modifying role of body fat distribution on this association.

Methods

We included 2210 postmenopausal women without prevalent diabetes at recruitment (2000-2002) from the Multiethnic Study of Atherosclerosis. Cox proportional hazards models were used to examine associations of MHT and MHT types with incident diabetes, testing for variation according to body fat distribution.

Results

Over a median follow-up of 11.1 years, there were 226 incident cases of diabetes. There were no significant interactions with central or generalized body fatness. In fully adjusted models, current and past MHT use was associated

SUBMITTER: Ebong IA 

PROVIDER: S-EPMC4968885 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature