Glutathione S-Transferase Deletion Polymorphisms in Early-Onset Psychotic and Bipolar Disorders: A Case-Control Study.

ABSTRACT:

Objective

To examine glutathione S-transferase (GST) deletion polymorphisms in development of early-onset severe mental disorders, with the hypothesis that patients with GSTM1-null and GSTT1-null genotypes will develop psychotic disorders at a younger age.

Methods

We identified GSTM1 and GSTT1 deletion polymorphisms by multiplex polymerase chain reaction (PCR) in 93 patients with early onset severe mental disorders and 278 control individuals. The diagnoses were confirmed by Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version and Schedule for Affective Disorders and Schizophrenia-Life-Time Version (K-SADS-PL) interviews.

Results

Individuals with the GSTM1-null genotype were at 3.36-fold higher risk of developing earl

SUBMITTER: Pejovic-Milovancevic MM 

PROVIDER: S-EPMC4985766 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature