Ontology highlight
ABSTRACT:
SUBMITTER: Mollereau B
PROVIDER: S-EPMC5010532 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mollereau B B Rzechorzek N M NM Roussel B D BD Sedru M M Van den Brink D M DM Bailly-Maitre B B Palladino F F Medinas D B DB Domingos P M PM Hunot S S Chandran S S Birman S S Baron T T Vivien D D Duarte C B CB Ryoo H D HD Steller H H Urano F F Chevet E E Kroemer G G Ciechanover A A Calabrese E J EJ Kaufman R J RJ Hetz C C
Brain research 20160302 Pt B
In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the unfolded protein response, the ubiquitin proteasome system and autophagy. Interesting ...[more]