Oncogene Mutations in Colorectal Polyps Identified in the Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study.
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ABSTRACT:
SUBMITTER: Lorentzen JA
PROVIDER: S-EPMC5015815 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Oncogene Mutations in Colorectal Polyps Identified in the Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study.
Lorentzen Jon A JA Grzyb Krzysztof K De Angelis Paula M PM Hoff Geir G Eide Tor J TJ Andresen Per Arne PA
Clinical medicine insights. Pathology 20160907
Data are limited on oncogene mutation frequencies in polyps from principally asymptomatic participants of population-based colorectal cancer screening studies. In this study, DNA from 204 polyps, 5 mm or larger, were collected from 176 participants of the NORCCAP screening study and analyzed for mutations in KRAS, BRAF, and PIK3CA including the rarely studied KRAS exons 3 and 4 mutations. KRAS mutations were identified in 23.0% of the lesions and were significantly associated with tubulovillous ...[more]
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