Dataset Information

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R ₂ and R ₂.

ABSTRACT:

Purpose

To compare three types of MRI liver iron content (LIC) measurement performed in daily clinical routine in a single center over a 6-year period.

Methods

Patients undergoing LIC MRI-scans (1.5T) at our center between January 1, 2008 and December 31, 2013 were retrospectively included. LIC was measured routinely with signal intensity ratio (SIR) and MR-relaxometry (R ₂ and R ₂*) methods. Three observers placed regions-of-interest. The success rate was the number of correctly acquired scans over the total number of scans. Interobserver agreement was assessed with intraclass correlation coefficients (ICC) and Bland-Altman analysis, correlations between LIC_SIR, R ₂, R ₂*, and serum values with Spearman's rank correlation coefficient. Diagnostic accuracies of LIC_SIR, R ₂ and serum transferrin, transferrin-saturation, and ferritin compared to increased R ₂* (≥44 Hz) as indicator of iron overload were assessed using ROC-analysis.

Results

LIC MRI-scans were performed in 114 subjects. SIR, R ₂, and R ₂* data were successfully acquired in 102/114 (89%), 71/114 (62%), and 112/114 (98%) measurements, with the lowest success rate for R ₂. The ICCs of SIR, R ₂, and R ₂* did not differ at 0.998, 0.997, and 0.999. R ₂ and serum ferritin had the highest diagnostic accuracies to detect elevated R ₂* as mark of iron overload.

Conclusions

SIR and R ₂* are preferable over R ₂ in terms of success rates. R ₂*'s shorter acquisition time and wide range of measurable LIC values favor R ₂* over SIR for MRI-based LIC measurement.

SUBMITTER: Runge JH

PROVIDER: S-EPMC5059419 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R <sub>2</sub> and R <sub>2</sub>.

Runge Jurgen H JH Akkerman Erik M EM Troelstra Marian A MA Nederveen Aart J AJ Beuers Ulrich U Stoker Jaap J

Abdominal radiology (New York) 20161101 11

<h4>Purpose</h4>To compare three types of MRI liver iron content (LIC) measurement performed in daily clinical routine in a single center over a 6-year period.<h4>Methods</h4>Patients undergoing LIC MRI-scans (1.5T) at our center between January 1, 2008 and December 31, 2013 were retrospectively included. LIC was measured routinely with signal intensity ratio (SIR) and MR-relaxometry (R <sub>2</sub> and R <sub>2</sub>*) methods. Three observers placed regions-of-interest. The success rate was th ...[more]

PMID: 27431019

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Project description:ObjectiveMultisystem iron poisoning is a major concern for long-term beta-thalassemia management. Quantitative MRI-based techniques routinely show iron overload in heart, liver, endocrine glands and kidneys. However, data on the brain are conflicting and monitoring of brain iron content is still matter of debate.MethodsThis 3T-MRI study applied a well validated high-resolution whole-brain quantitative MRI assessment of iron content on 47 transfusion-dependent (mean-age: 36.9 ± 10.3 years, 63% females), 23 non-transfusion dependent (mean-age: 29.2 ± 11.7 years, 56% females) and 57 healthy controls (mean-age: 33.9 ± 10.8 years, 65% females). Clinical data, Wechsler Adult Intelligence Scale scores and treatment regimens were recorded. Beside whole-brain R2* analyses, regional R2*-values were extracted in putamen, globus pallidum, caudate nucleus, thalamus and red nucleus; hippocampal volumes were also determined.ResultsRegional analyses yielded no significant differences between patients and controls, except in those treated with deferiprone that showed lower R2*-values (p<0.05). Whole-brain analyses of R2*-maps revealed strong age-R2* correlations (r2=0.51) in both groups and clusters of significantly increased R2*-values in beta-thalassemia patients in the hippocampal formations and around the Luschka foramina; transfusion treatment was associated with additional R2* increase in dorsal thalami. Hippocampal formation R2*-values did not correlate with hippocampal volume; hippocampal volume did not differ between patients and controls. All regions with increased R2*-values shared a strict anatomical contiguity with choroid plexuses suggesting a blooming effect as the likely cause of R2* increase, in agreement with the available histopathologic literature evidence.ConclusionAccording to our MRI findings and the available histopathologic literature evidence, concerns about neural tissue iron overload in beta-thalassemia appear to be unjustified.

Dataset Information

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R ₂ and R ₂.

Purpose

Methods

Results

Conclusions

Publications

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R <sub>2</sub> and R <sub>2</sub>.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R 2 and R 2.

Purpose

Methods

Results

Conclusions

Publications

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R <sub>2</sub> and R <sub>2</sub>.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R ₂ and R ₂.