Compartmentalized gene regulatory network of the pathogenic fungus Fusarium graminearum.

ABSTRACT: Head blight caused by Fusarium graminearum threatens world-wide wheat production, resulting in both yield loss and mycotoxin contamination. We reconstructed the global F. graminearum gene regulatory network (GRN) from a large collection of transcriptomic data using Bayesian network inference, a machine-learning algorithm. This GRN reveals connectivity between key regulators and their target genes. Focusing on key regulators, this network contains eight distinct but interwoven modules. Enriched for unique functions, such as cell cycle, DNA replication, transcription, translation and stress responses, each module exhibits distinct expression profiles. Evolutionarily, the F. graminearum genome can be divided into core regions shared with closely related species and variable regions harboring

SUBMITTER: Guo L 

PROVIDER: S-EPMC5069591 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature