Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5087075 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20161031
Innate immunity has been extended to respond environmental pathogen other than microbial components. Here we explore a novel pollen/TLR4 innate immunity in allergic inflammation. In experimental allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated IL-33/ST2 signaling and overproduced Th2 cytokine were observed in ocular surface, cervical lymph nodes and isolated CD4<sup>+</sup> T cells of BALB/c mice. These clinical, cellular and molecular changes wer ...[more]