Liver Monocytes and Kupffer Cells Remain Transcriptionally Distinct during Chronic Viral Infection.

ABSTRACT: Due to the scarcity of immunocompetent animal models for chronic viral hepatitis, little is known about the role of the innate intrahepatic immune system during viral replication in the liver. These insights are however fundamental for the understanding of the inappropriate adaptive immune responses during the chronic phase of the infection. We apply the Lymphocytic Choriomenigitis Virus (LCMV) clone 13 mouse model to examine chronic virus-host interactions of Kupffer cells (KC) and infiltrating monocytes (IM) in an infected liver. LCMV infection induced overt clinical hepatitis, with rise in ALT and serum cytokines, and increased intrahepatic F4/80 expression. Despite ongoing viral replication, whole liver transcriptome showed baseline expression levels of inflammatory cytokines, interfer

SUBMITTER: van de Garde MD 

PROVIDER: S-EPMC5094584 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature