Ontology highlight
ABSTRACT:
SUBMITTER: Stefely JA
PROVIDER: S-EPMC5101133 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Stefely Jonathan A JA Kwiecien Nicholas W NW Freiberger Elyse C EC Richards Alicia L AL Jochem Adam A Rush Matthew J P MJP Ulbrich Arne A Robinson Kyle P KP Hutchins Paul D PD Veling Mike T MT Guo Xiao X Kemmerer Zachary A ZA Connors Kyle J KJ Trujillo Edna A EA Sokol Jacob J Marx Harald H Westphall Michael S MS Hebert Alexander S AS Pagliarini David J DJ Coon Joshua J JJ
Nature biotechnology 20160926 11
Mitochondrial dysfunction is associated with many human diseases, including cancer and neurodegeneration, that are often linked to proteins and pathways that are not well-characterized. To begin defining the functions of such poorly characterized proteins, we used mass spectrometry to map the proteomes, lipidomes, and metabolomes of 174 yeast strains, each lacking a single gene related to mitochondrial biology. 144 of these genes have human homologs, 60 of which are associated with disease and 3 ...[more]