Ontology highlight
ABSTRACT:
SUBMITTER: Stefely JA
PROVIDER: S-EPMC5101133 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nature biotechnology 20160926 11
Mitochondrial dysfunction is associated with many human diseases, including cancer and neurodegeneration, that are often linked to proteins and pathways that are not well-characterized. To begin defining the functions of such poorly characterized proteins, we used mass spectrometry to map the proteomes, lipidomes, and metabolomes of 174 yeast strains, each lacking a single gene related to mitochondrial biology. 144 of these genes have human homologs, 60 of which are associated with disease and 3 ...[more]