Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes.

ABSTRACT:

Background

This study investigated the effect of lithium monotherapy on peripheral lymphocyte gene expression in bipolar disorder (BD).

Method

Twenty-two medication-free bipolar subjects (11 hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were included as controls but did not receive treatment. Blood RNA samples were collected at baseline and after 2 and 8 weeks of treatment. RNA expression was measured using the Affymetrix GeneChip® Human Gene 1.0 ST Array followed by Ingenuity pathways analysis. The results for the contrast of weeks 2 and 8 were not significantly different and were combined.

Results

In BD subjects, 56 genes showed significant (false discovery rate <0.1) expression changes from baseline; the eff

SUBMITTER: Anand A 

PROVIDER: S-EPMC5109991 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature