Catabolite and Oxygen Regulation of Enterohemorrhagic Escherichia coli Virulence.

ABSTRACT: The biogeography of the gut is diverse in its longitudinal axis, as well as within specific microenvironments. Differential oxygenation and nutrient composition drive the membership of microbial communities in these habitats. Moreover, enteric pathogens can orchestrate further modifications to gain a competitive advantage toward host colonization. These pathogens are versatile and adept when exploiting the human colon. They expertly navigate complex environmental cues and interkingdom signaling to colonize and infect their hosts. Here we demonstrate how enterohemorrhagic Escherichia coli (EHEC) uses three sugar-sensing transcription factors, Cra, KdpE, and FusR, to exquisitely regulate the expression of virulence factors associated with its type III secretion system (T3SS) when exposed to

SUBMITTER: Carlson-Banning KM 

PROVIDER: S-EPMC5120142 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature